kjhs Volume. 4, Issue 2 (2024)

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Contributor(s)

Idehen IC, Yibala O, Yakubu BS, Bankole JK, Asibor E, Dic-Ijiewere EO, Chelimo JJ & Iyevhobu KO
 

Keywords

Brain Drug Methylenedioxymethamphetamine Molly Wistar Rat
 

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Histomorphological findings in the brain of adult Wistar rats exposed to the ecstasy Pill; 3, 4 methylenedioxymethamphetamine

Abstract: In all vertebrates and the majority of invertebrates, the brain is the organ that acts as the hub of the nervous system. 3,4-methylenedioxymethamphetamine (MDMA), a derivative of amphetamine that affects the central nervous system (CNS), is marketed under the brand name Molly and is abused for its intoxicating recreational effects. Using adult Wistar rats, this study sought to ascertain the histomorphological effects of molly on the brain. The animal farm provided 25 adult Wistar rats with a mean weight of 110.10g, and segmented into five groups (A–E). Groups B through E were the test groups, and group A was the control. Molly was made in graded doses for Groups B through E, and the amount to be given was determined by weighing the dosages. Sections were taken from the samples and subjected to histological processing after brain tissues were removed and preserved in 10% formal saline for a full day. A segment of the brain including normal neurons with normochromic nuclei, pale cytoplasm, and normal glial cells was displayed in groups A (control), B, and E. There were typical fibrillary extensions in the backdrop. In conclusion, modest dosages of MDMA did not cause alterations in the brain associated with oxidative stress. Adult rats treated with MDMA did not exhibit changes in brain morphology or histology. To determine whether moderate MDMA dosages cause brain alterations in adult animals and whether these changes are permanent and might manifest later in maturity or old age, more research is needed.
 
 
 

KIU Journal of Health Sciences (KJHS) -- ISSN: 2790-945X, 2025 | All Articles