Nottingham Histological Grading of Cases of Primary Invasive Carcinoma of the Breast at LAUTECH Teaching Hospitals, Nigeria
Abstract:Breast cancer has since been known to be a global public health problem being the most common malignancy in women worldwide. The incidence in Nigeria is yet to be determined but is said to range from three and a half to thirteen and a half percent in hospital-based reports.
Our study aimed at grading the cases of primary invasive carcinoma of the breast using the Nottingham Histological System of grading.
The study was a hospital-based retrospective study carried out at LAUTECH Teaching Hospitals in Osogbo and Ogbomoso with ethical approval being obtained from the research and Ethics Committee of LAUTECH Teaching Hospital Ogbomoso. The original request cards were retrieved, studied and essential clinical details which include age, and the side (right or left) of the breast tumor were extracted. Tissue blocks were also retrieved and fresh sections about 3-5µm were cut from formalin-fixed and paraffin-embedded blocks and stained with Hematoxylin and Eosin dyes for histological analyses. Data obtained was analyzed using both Microsoft Excel and EPI Info statistical software and statistical package for social sciences. The information obtained was reported using frequencies and percentages. Quantitative data were presented as mean ± SD [Standard Deviation]. A 95% confidence interval was used in this study and a P-value of ≤ 0.05 was considered statistically significant.
Our study revealed the commonest histological variant of primary invasive carcinoma of the female breast to be infiltrating ductal carcinoma, not specified type with 305 cases (88.9%).