kjhs Volume. 3, Issue 2 (2023)


Obeagu, E.I., Obeagu, G.U. & Aja, P.M.


Pregnancy outcomes Obstetrics Antioxidants Maternal health Fetal health Oxidative stress

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Enhancing pregnancy outcomes: The role of antioxidants in obstetrics

Abstract: The physiological process of pregnancy is intricate and fraught with difficulties and potential problems that may affect the health of the mother and the fetus. Owing to its capacity to counteract oxidative stress, antioxidants have drawn a lot of interest from obstetricians as possible partners in enhancing pregnancy outcomes. This study examines the body of research on the function of antioxidants in obstetrics and how they affect different elements of pregnancy. Reactive oxygen species (ROS) and the body's antioxidant defense mechanisms are out of balance, and this imbalance can lead to oxidative stress, which has been linked to harmful pregnancy outcomes such as preterm birth, preeclampsia, and intrauterine growth restriction. One vital organ for fetal development, the placenta, is especially vulnerable to oxidative damage, which could result in difficulties. This review focuses on the many endogenous and exogenous sources of antioxidants as well as their methods of action in reducing oxidative stress in pregnancy. Selenium, polyphenols from fruits and vegetables, vitamins C and E, and other well researched antioxidants have demonstrated the potential to lower the risk of unfavorable pregnancy outcomes. The review also investigates the possible synergistic benefits of mixing several antioxidants for improved defense.